Anti-MAT1A monoclonal antibody, clone 6B9

Antibody Isotype

IgG1

Clone

6B9

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human MAT1A.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunofluorescence (1:200-1:1000) & The optimal working dilution should be determined by the end user.

Alternative Names

MAT1A; methionine adenosyltransferase I, alpha; S-adenosylmethionine synthase isoform type-1; MAT; MATA1; S adenosylmethionine synthetase; SAMS; SAMS1; MAT 1; MAT-I/III; adoMet synthase 1; adoMet synthetase 1; methionine adenosyltransferase 1; methionine

Entrez Gene ID

UniProt ID

Antigen Description

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

Pathway

Biological oxidations, organism-specific biosystem; Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Methionine degradation, organism-specific biosystem;