Specifications
Immunogen
Recombinant protein corresponding to human MAPKAPK5.
Applications
Application Notes
ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; PRAK; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; MK5; MK-5; MAPKAP-K5;
Product Background
Antigen Description
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
Pathway
MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem; p38 MAPK Signaling Pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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