This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
Pathway
Adaptive Immune System; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; CXCR3-mediated signaling events; CXCR4-mediated signaling events; Class I PI3K signaling events mediated by Akt; Constitutive PI3K/AKT Signaling in Cancer; Costimulation by the CD28 family
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