Recombinant fragment corresponding to a region within amino acids 529-804 of Human JIP2 (UniProt ID: Q13387).
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000;
Target
Alternative Names
MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2; IB2; IB-2; JIP2; PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; islet-brain 2; JNK-interacting protein 2; homologous to mouse JIP-1; JNK MAP kinase scaffold protein 2; JNK M
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.
Pathway
MAPK signaling pathway;
Citations
Publication ()
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COA
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