Anti-MAP4K5 (aa 361-470) polyclonal antibody

Species Reactivity

Human

Immunogen

MAP4K5 (AAH36013, 361 a.a. ~ 470 a.a) partial recombinant protein with GST tag. The sequence is SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPD SESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLP

Conjugate

Alternative Names

MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5; KHS; GCKR; KHS1; MAPKKKK5; MEKKK 5; MEK kinase kinase 5; germinal center kinase-related; MAPK/ERK kinase kinase kinase 5; kinase homologous to SPS1/STE20;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Pathway

Insulin Signaling.