Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Pathway
Adaptive Immune System; CD28 co-stimulation; CD28 dependent PI3K/Akt signaling; Costimulation by the CD28 family; Cytokine Signaling in Immune system; Immune System; Insulin Signaling.
Citations
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COA
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