Anti-MANEA monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human MANEA is used for rabbit immunization.

Conjugate

Alternative Names

MANEA; mannosidase, endo-alpha; ENDO; hEndo; glycoprotein endo-alpha-1,2-mannosidase; mandaselin; endomannosidase; endo-alpha mannosidase; alpha 1,2-endomannosidase;

Entrez Gene ID

UniProt ID

Antigen Description

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]

Pathway

Asparagine N-linked glycosylation; Metabolism of proteins; N-glycan trimming and elongation in the cis-Golgi; Post-translational protein modification; Transport to the Golgi and subsequent modification;