Anti-MAGED1 (aa 1-130) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human MAGED1 aa 1-130 (N terminal).Sequence: MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAAS PQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNA KDVPNTQPKAAFKSQNATPK GPNAAYDFSQ Database link: Q9Y5V3

Conjugate

Application Notes

IHC-P: 1/50 - 1/200; WB: 1/500 - 1/2000.

Alternative Names

MAGED1; melanoma antigen family D, 1; melanoma-associated antigen D1; DLXIN 1; NRAGE; MAGE-D1 antigen; MAGE tumor antigen CCF; neurotrophin receptor-interacting MAGE homolog; DLXIN-1;

Entrez Gene ID

UniProt ID

Antigen Description

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53 transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Pathway

Apoptosis; Cell death signalling via NRAGE, NRIF and NADE; NRAGE signals death through JNK; Neurotrophic factor-mediated Trk receptor signaling; Neurotrophin signaling pathway; Regulation of Apoptosis;