Anti-Lymphotoxin Alpha + Beta monoclonal antibody, clone NN1571-23C5

Antibody Isotype

IgG1

Clone

NN1571-23C5

Species Reactivity

Human

Immunogen

Recombinant full length Human Lymphotoxin Alpha + Beta.

Conjugate

Alternative Names

LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1; LT-alpha; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1;

Entrez Gene ID

UniProt ID

Antigen Description

Lymphotoxin Alpha, which is a member of the TNF family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with Lymphotoxin Beta which anchors Lymphotoxin Alpha to the cell surface. This protein is also involved in the formation of secondary lymphoid organs during development, mediates a variety of inflammatory, immunostimulatory, and antiviral responses, and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis. Lymphotoxin Beta is a type II membrane protein of the TNF family. It anchors Lymphotoxin Alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the Lymphotoxin Alpha 1/Beta 2 complex (e.g. 1 molecule alpha/2 molecules beta), which is the primary ligand for the Lymphotoxin Beta receptor. The minor complex is Lymphotoxin Alpha 2/Beta 1. Lymphotoxin Beta is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin Beta isoform b is unable to complex with Lymphotoxin Alpha suggesting a function for Lymphotoxin Beta which is independent of Lymphotoxin Alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Pathway

Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem.