Anti-LAMB1 monoclonal antibody (DMABT-H21615)

Rat anti-Mouse LAMB1 monoclonal antibody for ELISA, RIA, WB, IP, IHC Datasheet

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Specifications


Host Species
Rat
Antibody Isotype
IgM
Clone
BM-6
Species Reactivity
Mouse
Immunogen
Laminin isolated from mouse EHS tumor.
Conjugate
Unconjugated

Target


Alternative Names
LAMB1; laminin B1; laminin subunit beta-1; laminin B1 chain; laminin B1 subunit 1; laminin-1 subunit beta
Entrez Gene ID
UniProt ID

Product Background


Gene summary
LAMB1 (Laminin Subunit Beta 1) is a Protein Coding gene. Diseases associated with LAMB1 include lissencephaly 5 and cobblestone lissencephaly without muscular or ocular involvement. Among its related pathways are Degradation of the extracellular matrix and Developmental Biology. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Antigen Description
Lissencephaly 5 (LIS5) [MIM:615191]: An autosomal recessive brain malformation characterized by cobblestone changes in the cortex, more severe in the posterior region, and subcortical band heterotopia. Affected individuals have hydrocephalus, seizures, and severely delayed psychomotor development. Note=The disease is caused by mutations affecting the gene represented in this entry. Laminin subunit beta-1 is a protein that in humans is encoded by the LAMB1 gene. 0The function about LAMB1 antigen include enzyme binding; extracellular matrix structural constituent; glycosphingolipid binding; integrin binding; protein binding.
Pathway
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem.

Citations


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References


Sharif, KA; Baker, H; et al. Differential regulation of laminin B1 transgene expression in the neonatal and adult mouse brain. NEUROSCIENCE 126:967-978(2004).
SOROKIN, L; GIRG, W; et al. EXPRESSION OF NOVEL 400-KDA LAMININ CHAINS BY MOUSE AND BOVINE ENDOTHELIAL-CELLS. EUROPEAN JOURNAL OF BIOCHEMISTRY 223:603-610(1994).

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