General Notes
This product (Catalog No. DPABH-04295) is a rabbit-derived polyclonal antibody raised against human LSS, targeting the amino acid region 388–549 of the protein. This antibody exhibits cross-reactivity with Human LSS from mouse and rat. It has been affinity purified by Protein A. Lanosterol synthase (LSS; EC 5.4.99.7), also known as oxidosqualene cyclase (OSC), is a monotopic membrane-bound enzyme that catalyzes the cyclization of the linear triterpene 2,3-oxidosqualene to lanosterol, generating the protosterol cation intermediate and forming the four-ring sterol scaffold with seven chiral centers in a highly stereospecific and exothermic reaction. This step represents the first committed cyclization in the de novo biosynthesis of cholesterol and other sterols, such as ergosterol in fungi, and is essential for producing the core structure of all eukaryotic sterols.
DPABH-04295 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-04295 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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