Anti-LRRC45 (aa 622-651) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human LRRC45 aa 622-651 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q96CN5

Conjugate

Application Notes

ICC/IF: 1/10 - 1/50; Flow Cyt: 1/10 - 1/50; IHC-P: 1/50 - 1/100; WB: 1/100 - 1/500;

Alternative Names

LRRC45; leucine rich repeat containing 45; leucine-rich repeat-containing protein 45;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.