Anti-LRP6 monoclonal antibody (DCABH-9617) Knockout Validated

Mouse anti-Human LRP6 monoclonal antibody for WB, IP

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2D21
Species Reactivity
Mouse, Human
Immunogen
Cytoplasmic domain of human LRP6.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/2000; IP: 1/1000 - 1/2000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LRP6; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; ADCAD2; FLJ90062
Entrez Gene ID
UniProt ID

Product Background


Pathway
Canonical Wnt signaling pathway, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Presenilin action in Notch and Wnt signaling, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling network, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem;

Citations


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References


Zhang, JN; Shemezis, JR; et al. AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development. NEURAL DEVELOPMENT 8:-(2013).
Glantschnig, H; Scott, K; et al. A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 338:568-578(2011).

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