LOXL4 (NP_115587, 657 a.a. ~ 755 a.a) partial recombinant protein with GST tag. The sequence is ACANFGEQGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQ CRCKYDGHRVWLHNCHTGNSYPANAELSLEQEQRLRNNL
Conjugate
Unconjugated
Target
Alternative Names
LOXL4; lysyl oxidase-like 4; LOXC; lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like protein 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-related protein C;
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Pathway
Assembly of collagen fibrils and other multimeric structures; Crosslinking of collagen fibrils; Extracellular matrix organization.
Citations
Publication ()
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