LMBR1 (NP_071903, 214 a.a. ~ 295 a.a) partial recombinant protein with GST tag. The sequence is SRMFTVMGQLLVKPTILEDLDEQIYIITLEEEALQRRLNGLSSSVEYNIMELEQELENVK TLKTKLERRKKASAWERNLVYP
Conjugate
Unconjugated
Target
Alternative Names
LMBR1; limb development membrane protein 1; TPT; ZRS; ACHP; PPD2; DIF14; C7orf2; limb region 1 protein homolog; limb region 1 homolog; differentiation-related gene 14 protein;
This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.
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