Anti-LIN7C (aa 1-50) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within the N terminal amino acids 1-50 (AALGEPVRLE RDICRAIELL EKLQRSGEVP PQKLQALQRV LQSEFCNAVR) of Human LIN7C (NP_060832).

Conjugate

Application Notes

IHC-P: 5 μg/ml; WB: 1 μg/ml;

Alternative Names

LIN7C; lin-7 homolog C (C. elegans); MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C; protein lin-7 homolog C; veli-3; LIN-7 protein 3; vertebrate lin-7 homolog 3; mammalian lin-seven protein 3;

Entrez Gene ID

UniProt ID

Antigen Description

LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.