Anti-LIN7A polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 179-207 of Human LIN7A (NP_004655.1).

Conjugate

Unconjugated

Application Notes

WB: 1/100 - 1/500.

Alternative Names

LIN7A; lin-7 homolog A (C. elegans); LIN7; VELI1; LIN-7A; MALS-1; TIP-33; protein lin-7 homolog A; hLin-7; veli-1; mammalian LIN-7 1; vertebrate LIN7 homolog 1; tax interaction protein 33; vertebrate lin-7 homolog 1; mammalian lin-seven protein 1;

Entrez Gene ID

8825

UniProt ID

O14910

Antigen Description

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More