Anti-LCLAT1 polyclonal antibody (DPABH-20493)

Rabbit anti-Human LCLAT1 (aa 231-307) polyclonal antibody for IHC-P

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
antigen sequence, corresponding to amino acids 231-307 (LHPRTTGFTF VVDRLREGKN LDAVHDITVA YPHNIPQSEK HLLQGDFPRE IHFHVHRYPI DTLPTSKEDL QLWCHKR) of Human LCLAT1.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/200 - 1/500.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LCLAT1; lysocardiolipin acyltransferase 1; LYCAT; AGPAT8; ALCAT1; 1AGPAT8
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. The function about LCLAT1 antigen include 1-acylglycerol-3-phosphate O-acyltransferase activity.
Pathway
Acyl chain remodeling of CL; Fatty acid, triacylglycerol, and ketone body metabolism; Glycerolipid metabolism; Glycerophospholipid metabolism.

Citations


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References


Cao, JS; Shen, WQ; et al. ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 296:E647-E653(2009).
Nie, J; Hao, XB; et al. A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1801:438-445(2010).

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