Anti-LAMTOR3 (aa 1-87) polyclonal antibody

Species Reactivity

Human

Immunogen

MAPKSP1 (NP_068805, 1 a.a. ~ 87 a.a) partial recombinant protein with GST tag. The sequence is MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNAPEHALRPGFLSTFALATDQG SKLGLSKNKSIICYYNTYQVVQFNRLP

Conjugate

Alternative Names

LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3; ragulator complex protein LAMTOR3; MEK binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.

Pathway

MAPK signaling pathway.