Anti-KCNU1 monoclonal antibody, clone T3-27

Antibody Isotype

IgG2b

Clone

T3-27

Species Reactivity

Mouse

Immunogen

Recombinant protein corresponding to amino acids 1052-1121 of mouse Kcnu1.

Conjugate

Application Notes

WB (1-10 μg/mL); Immunohistochemistry (0.1-1.0 μg/mL); Immunocytochemistry (0.1-1.0 μg/mL); Immunofluorescence (1-10 μg/mL) & The optimal working dilution should be determined by the end user.

Alternative Names

KCNU1; potassium channel, subfamily U, member 1; potassium channel subfamily U member 1; slowpoke homolog 3; pH-sensitive maxi potassium channel; calcium-activated potassium channel subunit alpha-3; calcium-activated potassium channel, subfamily M subunit

Entrez Gene ID

UniProt ID

Antigen Description

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina.

Pathway

Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem;