Recombinant fragment corresponding to Human KSR2 aa 122-950.Sequence: MTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWP TTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVY THVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTV TPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIP
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml.
Target
Alternative Names
KSR2; kinase suppressor of ras 2; kinase suppressor of Ras 2; FLJ25965;
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Citations
Publication ()
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