Anti-KRIT1 (aa 637-736) polyclonal antibody

Species Reactivity

Human

Immunogen

KRIT1 (NP_004903, 637 a.a. ~ 736 a.a) partial recombinant protein with GST tag. The sequence is AAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLKYGCFMWQLGDTDTC FQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPTERNS

Conjugate

Alternative Names

KRIT1; KRIT1, ankyrin repeat containing; CAM; CCM1; krev interaction trapped protein 1; krev interaction trapped 1; ankyrin repeat-containing protein Krit1; cerebral cavernous malformations 1 protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.

Pathway

Hypothetical Network for Drug Addiction.