Recombinant fragment corresponding to Human C3IP1 aa 177-405. Produced in E.coli (NP_067646).Sequence: GEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPL LTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRAR LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVS
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/150; WB: 1/500.
Target
Alternative Names
KLHL12; kelch-like 12 (Drosophila); kelch-like protein 12; C3IP1; kelch-like protein C3IP1; CUL3-interacting protein 1; DKIR; FLJ27152;
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
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