Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Pathway
Aurora B signaling; Cell Cycle; Cell Cycle, Mitotic; DNA Replication; Factors involved in megakaryocyte development and platelet production; Hemostasis; Kinesins
Citations
Publication ()
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