General Notes
This product (Catalog No. DPABH-20117) is a rabbit-derived polyclonal antibody raised against human KIF18B, targeting the amino acid region 1–110 of the protein. It has been affinity purified by Protein A. KIF18B is a key member of the kinesin-8 family, involved in regulating various physiological processes such as microtubule length, spindle assembly, and chromosome alignment. This article briefly introduces the structure and physiological functions of KIF18B, examines its role in malignant tumors, and the associated carcinogenic signaling pathways such as PI3K/AKT, Wnt/β-catenin, and mTOR pathways. Research indicates that the upregulation of KIF18B enhances tumor malignancy and resistance to radiotherapy and chemotherapy. KIF18B could become a new target for anticancer drugs, offering significant potential for the treatment of malignant tumors and reducing chemotherapy resistance (PMID: 39259333).
DPABH-20117 is suitable for use in IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate), IF/ICC (1:200–1:800) applications.
DPABH-20117 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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