KIAA1598 (KIAA1598) is a protein-coding gene. Diseases associated with KIAA1598 include cleft palate, and cleft lip, and among its related super-pathways are Axon guidance. GO annotations related to this gene include kinase binding. Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity).
Pathway
Axon guidance; Developmental Biology; L1CAM interactions; Recycling pathway of L1.
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