Synthetic peptide within Human Rubicon aa 249-278 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q92622
KIAA0226; SCAR15; RUBICON; run domain Beclin-1 interacting and cysteine-rich containing protein; baron; rundataxin; beclin-1 associated RUN domain containing protein; run domain Beclin-1 interacting and cystein-rich containing protein; RUN domain protein
The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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