Anti-KDM2A (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human FBXL11 aa 1-782.Sequence: MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYN ANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKM CVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSH TRLENMVQRPSTVDFIDWVDNMWPRHLKESQTE

Conjugate

Application Notes

WB: 1 μg/ml;

Alternative Names

KDM2A; lysine (K)-specific demethylase 2A; FBL7; CXXC8; FBL11; FBXL11; JHDM1A; LILINA; lysine-specific demethylase 2A; F-box/LRR-repeat protein 11; CXXC-type zinc finger protein 8; [Histone-H3]-lysine-36 demethylase 1A; F-box and leucine-rich repeat prote

Entrez Gene ID

UniProt ID

Antigen Description

Histone demethylase that specifically demethylates Lys-36 of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 Lys-36 residue while it has weak or no activity for mono- and tri-methylated H3 Lys-36. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.