Anti-KCNJ12 monoclonal antibody, clone T235C-49

Antibody Isotype

IgG1

Clone

T235C-49

Species Reactivity

Rat

Immunogen

Fusion protein, corresponding to amino acids 362-427 of Rat Kir2.2 (NP_446433).

Conjugate

Application Notes

WB: Use a concentration of 1 - 10 μg/ml. Predicted molecular weight: 49 kDa; IHC-P: Use a concentration of 5 μg/ml. ICC/IF: Use a concentration of 0.1 - 1 μg/ml.

Alternative Names

KCNJ12; potassium inwardly-rectifying channel, subfamily J, member 12; ATP-sensitive inward rectifier potassium channel 12; IRK-2; inward rectifier K(+) channel Kir2.2; potassium channel, inwardly rectifying subfamily J member 12; IRK2; Kir2.2; MB-IRK2; M

Entrez Gene ID

UniProt ID

Antigen Description

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.

Pathway

Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem; GABA B receptor activation, organism-specific biosystem; GABA receptor activation, organism-specific biosystem; Inhibitionof voltage gated Ca2+ channels via Gbeta/gamma subunits, organism-specific biosystem;