Anti-KCNJ11 (internal region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide corresponding to an internal sequence of Human Kir6.2.

Conjugate

Application Notes

WB: 1/500 - 1/1000; ELISA: 1/10000; IHC-P: 10 μg/ml; ICC/IF: 1/100 - 1/500;

Alternative Names

KCNJ11; potassium inwardly-rectifying channel, subfamily J, member 11; BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2; ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; inward rectifier K(+) channel Kir6.2; inwardly rectifyin

Entrez Gene ID

UniProt ID

Antigen Description

ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.

Pathway

ATP sensitive Potassium channels; Insulin secretion; Inwardly rectifying K+ channels; Neuronal System