Anti-KCNIP3 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

CSEN (AAH12850, 1 a.a. ~ 256 a.a) full-length recombinant protein with GST tag. The sequence is MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGS DSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQ FFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDG YITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQ KDENIMSSMQLFENVI

Conjugate

Alternative Names

KCNIP3; Kv channel interacting protein 3, calsenilin; CSEN; DREAM; KCHIP3; calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenil

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.

Pathway

IL-3 Signaling Pathway;