An animal model of MGRS: what advances await?
BLOOD
Authors: Leung, Nelson
Abstract
In this issue of Blood, Bender et al report the successful development of a model of light chain (LC) deposition disease using knockin kappa LC gene in a transgenic mouse model.(1) This model reproduces all the features of the human disease, but it does not rely on myeloma cells, which have been a double-edged sword in other models.
The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL)
LEUKEMIA & LYMPHOMA
Authors: Maiolo, Elena; Alma, Eleonora; Napodano, Cecilia; Gulli, Francesca; Bellesi, Silvia; Cuccaro, Annarosa; Pocino, Krizia; D'Alo', Francesco; Iachini, Marco; Martini, Maurizio; Larocca, Luigi Maria; De Stefano, Valerio; Basile, Umberto; Hohaus, Stefan
Abstract
We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of kappa-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and kappa-FLC >50 mg/L had a significant inferior event-free survival (p = .004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p = .008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein.
COA
Publication 
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