Anti-IYD monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human IYD is used for rabbit immunization.

Conjugate

Alternative Names

IYD; iodotyrosine deiodinase; TDH4; DEHAL1; C6orf71; dJ422F24.1; iodotyrosine dehalogenase 1; IYD-1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.

Pathway

Amine-derived hormones; Metabolism; Metabolism of amino acids and derivatives; Thyroid hormone synthesis; Thyroid hormone synthesis; Thyroxine biosynthesis;