Synthetic peptide: HDKETYKLQRRETIK with a Cysteine residue linker, corresponding to internal sequence amino acids 224-238 of Human ITM2B (NP_068839.1).
Conjugate
Unconjugated
Target
Alternative Names
ITM2B; integral membrane protein 2B; BRI; E3 16; E25B; ABri/ADan amyloid peptide; transmembrane protein BRI; BRICHOS domain containing 2B; FBD; ABRI; BRI2; E3-16; BRICD2B;
Functions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence.
Pathway
Amyloids; Disease; IL-2 Signaling Pathway;
Citations
Publication ()
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COA
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