Anti-ITGAD monoclonal antibody, clone DB27.4E4

Name: Anti-ITGAD monoclonal antibody, clone DB27.4E4
SKU: DCABY-289
Rating: 5 (1 reviews)

Mouse anti-Dog ITGAD monoclonal antibody for IHC-Fr, FC

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG2b

Clone

DB27.4E4

Species Reactivity

Dog; Cat; Pig

Immunogen

Affinity purified CD11 antigen from canine spleen.

Conjugate

Unconjugated

Applications

Application Notes

Flow Cyt: Neat

Target

Alternative Names

ITGAD; CD11d; integrin, alpha D

Entrez Gene ID

489930

UniProt ID

F1Q1L9

Product Background

Antigen Description

The alpha d integrin (CD11d) subunit is expressed as a heterodimer with beta 2 integrin (CD18). CD11d is expressed by a sub-population of macrophages, some CD8 positive T cells and by gamma/delta T cells in the splenic red pulp.Over expression of CD11d is noted in histiocytic disorders including Hemophagocytic sarcoma, described as a proliferative disorder specifically of CD11+ macrophages with macrophages demonstrating marked erythrocytic phagocytosis. Previously, canine histiocytic sarcoma were described as originating entirely from interstitial dendritic cells. Cells from animals with canine hepatosplenic T-cell lymphoma (HTSL) strongly express CD11d on malignant cells. Dogs normally demonstrate strong positivity for CD11d on large granular lymphocytes, macrophages and T cells in the splenic red pulp. CD11+ gamma;/delta; T cells constitute ~30% red pulp T cells despite their rarity in peripheral blood, suggesting a splenic red pulp origin of HTSL.

Pathway

Axon guidance; B Cell Receptor Signaling Pathway; Cell adhesion molecules (CAMs); Developmental Biology; EPO Receptor Signaling; Fc gamma R-mediated phagocytosis; Other semaphorin interactions; Primary immunodeficiency; Semaphorin interactions; T cell receptor signaling pathway

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Cloning and chromosomal localization of a novel gene-encoding a human beta(2)-integrin alpha subunit

GENE

Authors: Wong, DA; Davis, EM; LeBeau, M; Springer, TA

Abstract

We isolated a partial genomic clone encoding ITGAD, a novel beta(2)-integrin alpha subunit. The ITGAD gene is highly homologous to the three previously known alpha subunit-encoding genes, that compose the beta(2) integrin family, in deduced amino acid sequence, intron/exon structure and mapping location (chromosome 16p11).

Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma

SCIENTIFIC REPORTS

Authors: Zhang, J.; Huang, J. Y.; Chen, Y. N.; Yuan, F.; Zhang, H.; Yan, F. H.; Wang, M. J.; Wang, G.; Su, M.; Lu, G.; Huang, Y.; Dai, H.; Ji, J.; Zhang, J.; Zhang, J. N.; Jiang, Y. N.; Chen, S. J.; Zhu, Z. G.; Yu, Y. Y.

Abstract

Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease. Currently, there are limited clinical approaches for predicting and treatment of peritoneal metastasis, resulting in a 6-month average survival time. By comprehensive genome analysis will uncover the pathogenesis of peritoneal metastasis. Here we describe a comprehensive whole-genome and transcriptome sequencing analysis of one advanced gastric cancer case, including non-cancerous mucosa, primary cancer and matched peritoneal metastatic cancer. The peripheral blood is used as normal control. We identified 27 mutated genes, of which 19 genes are reported in COSMIC database (ZNF208, CRNN, ATXN3, DCTN1, RP1L1, PRB4, PRB1, MUC4, HS6ST3, MUC17, JAM2, ITGAD, IREB2, IQUB, CORO1B, CCDC121, AKAP2, ACAN and ACADL), and eight genes have not previously been described in gastric cancer (CCDC178, ARMC4, TUBB6, PLIN4, PKLR, PDZD2, DMBT1and DAB1). Additionally, GPX4 and MPND in 19q13.3-13.4 region, is characterized as a novel fusion-gene. This study disclosed novel biological markers and tumorigenic pathways that would predict gastric cancer occurring peritoneal metastasis.