Anti-ITGA1 monoclonal antibody, clone TS2/7 [Biotin]

Ovarian cancer is a serious threat to women's health. Drug resistance is a major cause of post-treatment relapses, metastasis, and even death, and thus it is a main obstacle to the survival of ovarian cancer patients. Cell adhesion-mediated drug resistance (CAM-DR) was considered to play a critical role in ovarian cancer drug resistance. In this study, FN1, ITGA1 and ITGA5 were identified as central genes in regulation of drug resistance in ovarian cancer through CAM-DR, and their expression in cisplatin-resistant SKOV3 (SKOV3/DDP2) cells, cisplatin-resistant A2780 (A2780/DDP) cells, and in 54 cases of drug-resistant tissues were dysregulated when compared with their expression incontrols, as measured by RT-qPCR and immunohistochemical analysis. Furthermore, the low expression of ITGA1 is notably associated with poor outcome. Thus our findings suggest that ITGA1 might participate in the regulation of drug resistance in ovarian cancer and serve as a potential biomarker for prognosis of ovarian cancer.