Mouse anti-Human IREB2 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein, corresponding to amino acids 1-343 of Human IREB2 (AAH17880.1).

Conjugate

Alternative Names

IREB2; iron-responsive element binding protein 2; iron-responsive element-binding protein 2; IRP2; IRE-BP 2; iron regulatory protein 2; ACO3; IRP2AD; FLJ23381;

Entrez Gene ID

UniProt ID

Antigen Description

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Pathway

Validated targets of C-MYC transcriptional activation;