antigen sequence: PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE, corresponding to N terminal amino acids 28-96 of Human IQSEC1 protein (UniProt ID: Q6DN90).
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/50 - 1/200. ICC/IF: 1 - 4 μg/ml.
Target
Alternative Names
IQSEC1; IQ motif and Sec7 domain 1; BRAG2; GEP100; ARFGEP100; ARF-GEP100; IQ motif and SEC7 domain-containing protein 1; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; ADP-ribosylation factors guanine nucleotide-exchange protein 2;
In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
Pathway
Arf6 signaling events; Endocytosis.
Citations
Publication ()
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