Anti-IQSEC1 polyclonal antibody (DPABH-20744)

Rabbit anti-Human IQSEC1 (aa 28-96) polyclonal antibody for IHC-P, ICC/IF Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
antigen sequence: PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE, corresponding to N terminal amino acids 28-96 of Human IQSEC1 protein (UniProt ID: Q6DN90).
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/50 - 1/200. ICC/IF: 1 - 4 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
IQSEC1; IQ motif and Sec7 domain 1; BRAG2; GEP100; ARFGEP100; ARF-GEP100
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene. The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling. ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.
Pathway
Arf6 signaling events; Endocytosis.

Citations


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References


Someya, A; Sata, M; et al. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98:2413-2418(2001).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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