Anti-IQSEC1 polyclonal antibody (DPABH-20744)
Rabbit anti-Human IQSEC1 (aa 28-96) polyclonal antibody for IHC-P, ICC/IF
Bring this labeled antibody directly to your bench!
Add to basket
antigen sequence: PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE, corresponding to N terminal amino acids 28-96 of Human IQSEC1 protein (UniProt ID: Q6DN90).
IHC-P: 1/50 - 1/200. ICC/IF: 1 - 4 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
IQSEC1; IQ motif and Sec7 domain 1; BRAG2; GEP100; ARFGEP100; ARF-GEP100
In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP100 (ADP-Ribosylation Factor - Guanine nucleotide-Exchange Protein - 100-kDa) is a protein that in humans is encoded by the IQSEC1 gene. The ARF-GEP100 protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP100, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling. ARF-GEP100 appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.
Arf6 signaling events; Endocytosis.
Have you cited DPABH-20744 in a publication? Let us know
and earn a reward for your research.
Someya, A; Sata, M; et al. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98:2413-2418(2001).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.