Anti-IPO5 monoclonal antibody, clone 2D5

Antibody Isotype

IgG1

Clone

2D5

Species Reactivity

Human

Immunogen

Recombinant fragment, corresponding to amino acids 1-101 of Human Karyopherin beta 3, with a proprietary tag (AAH01497).

Conjugate

Application Notes

Sandwich IHC-P: 5 μg/ml.

Alternative Names

IPO5; importin 5; karyopherin (importin) beta 3 , KPNB3, RAN binding protein 5 , RANBP5; importin-5; IMB3; MGC2068; Pse1; karyopherin beta-3; RAN binding protein 5; ran-binding protein 5; importin beta-3 subunit; importin subunit beta-3; Ran_GTP binding

Entrez Gene ID

UniProt ID

Antigen Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

Pathway

Disease, organism-specific biosystem; Influenza Infection, organism-specific biosystem; Influenza Life Cycle, organism-specific biosystem; Influenza Viral RNA Transcription and Replication, organism-specific biosystem; vRNP Assembly, organism-specific biosystem;