Mouse anti-Human ING3 polyclonal antibody

Species Reactivity

Human

Immunogen

ING3 (NP_938008, 1 a.a. ~ 92 a.a) partial recombinant protein with GST tag. The sequence is MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREE QMASIKKDYYKALEDADEKVQLANQIYDLQHF

Conjugate

Alternative Names

ING3; inhibitor of growth family, member 3; Eaf4; ING2; MEAF4; p47ING3; inhibitor of growth protein 3;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Pathway

Chromatin modifying enzymes; HATs acetylate histones;