Anti-IL18BP monoclonal antibody (DCABH-9101)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQ2199Z
Species Reactivity
Rat, Human
Immunogen
A synthetic peptide corresponding to residues near the N-terminus of human IL18BP.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000 - 1/5000; Flow Cyt: 1/10;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; IL18BPa; MC51L 53L 54L homolog gene product; IL-18BP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IL18BP (Interleukin 18 Binding Protein) is a Protein Coding gene. Diseases associated with IL18BP include molluscum contagiosum and crohns disease. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor antagonist activity and interleukin-18 binding. The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Antigen Description
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene. 0The function about IL18BP antigen include interleukin-18 binding; receptor antagonist activity.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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Rabbit IgG Isotype Control CABT-B8382 IA Rabbit PDF Inquiry

References


Murray, DR; Mummidi, S; et al. beta 2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 52:206-218(2012).

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