Anti-IGFBP2 monoclonal antibody, clone 260203

Antibody Isotype

IgG2b

Clone

260203

Species Reactivity

Mouse

Immunogen

Mouse myeloma cell line NS0-derived recombinant mouse IGFBP-2. Glu35-Gln305 Accession Number CAA57270

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4243 - DPABY-523

Alternative Names

IGFBP2; insulin-like growth factor binding protein 2; IBP-2; Igfbp-2; AI255832; mIGFBP-2; insulin-like growth factor-binding protein 2; IGF-binding protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

Pathway

Metabolism of proteins; Myometrial Relaxation and Contraction Pathways; PodNet: protein-protein interactions in the podocyte; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); XPod