Anti-IGFBP1 monoclonal antibody, clone 44738

Antibody Isotype

IgG1

Clone

44738

Species Reactivity

Human

Immunogen

E. coli-derived recombinant human IGFBP-1

Conjugate

Application Notes

Western Blot: 1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-3967 - DPABY-458

Alternative Names

IGFBP1; insulin-like growth factor binding protein 1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; insulin-like growth factor-binding protein 1; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; placental protein 12; IGF-binding protein

Entrez Gene ID

UniProt ID

Antigen Description

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

Pathway

ATF4 activates genes; AhR pathway; FOXA2 and FOXA3 transcription factor networks; HIF-1-alpha transcription factor network; Metabolism of proteins; Myometrial Relaxation and Contraction Pathways; PERK regulates gene expression; Regulation of Insulin-like