Anti-IFNLR1 (aa 485-513) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 485-513 of Human IL28 Receptor alpha (NP_734464.1).

Conjugate

Application Notes

WB: 1/100 - 1/500;

Alternative Names

IFNLR1; interferon, lambda receptor 1; IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1; interferon lambda receptor 1; CRF2-12; IL-28RA; IL-28R-alpha; IFN-lambda-R1; IFN-lambda receptor 1; interleukin 28 receptor A; IL-28 receptor subunit alpha; interferon lambda,

Entrez Gene ID

UniProt ID

Antigen Description

IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

Pathway

Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Type III interferon signaling;