Anti-CSH1 monoclonal antibody (DCABH-404)

Mouse anti-Human CSH1 monoclonal antibody for RIA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
JOO-iQM-48
Species Reactivity
Human
Immunogen
Human placental lactogen.
Conjugate
Unconjugated

Target


Alternative Names
CSH1; chorionic somatomammotropin hormone 1 (placental lactogen); chorionic somatomammotropin hormone; choriomammotropin; chorionic somatomammotropin A; CSA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CSH1 (Chorionic Somatomammotropin Hormone 1) is a Protein Coding gene. Diseases associated with CSH1 include choriocarcinoma and silver-russell syndrome. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include hormone activity. An important paralog of this gene is CSHL1. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.
Antigen Description
Placental lactogen is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. The function about CSH1 antigen include hormone activity; metal ion binding.
Pathway
Cytokine Signaling in Immune system, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; Immune System, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem.

Citations


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References


Tuttle, TR; Hugo, ER; et al. Placental Lactogen Is Expressed but Is Not Translated into Protein in Breast Cancer. PLOS ONE 9:-(2014).
Singleton, DR; Hazen, KC; et al. Differential surface localization and temperature-dependent expression of the Candida albicans CSH1 protein. MICROBIOLOGY-SGM 150:285-292(2004).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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