Anti-VAMP7 monoclonal antibody (CABT-37960MH)

Mouse anti-Human VAMP7 monoclonal antibody for FC, ICC/IF, WB, IHC-Fr, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
25G579
Species Reactivity
Rat, Human
Immunogen
Recombinant full SYBL1 protein (Human)
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1/50; WB: 1/500 - 1/2000; IHC-Fr: 1/10 - 1/400;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
VAMP7; vesicle-associated membrane protein 7; SYBL1,synaptobrevin like 1; TI VAMP; VAMP 7; FLJ53045
Entrez Gene ID
UniProt ID

Product Background


Gene summary
VAMP7 (Vesicle Associated Membrane Protein 7) is a Protein Coding gene. Diseases associated with VAMP7 include tetanus and 46,xy partial gonadal dysgenesis. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.
Antigen Description
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants. Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene. VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. The function about VAMP7 antigen include protein binding.
Pathway
Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Lysosome Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; SNARE interactions in vesicular transport, organism-specific biosystem; SNARE interactions in vesicular transport, conserved biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem.

Citations


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References


Pryor, PR; Mullock, BM; et al. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events. EMBO REPORTS 5:590-595(2004).
Thomas, DDH; Martin, CL; et al. Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 298:C725-C739(2010).

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