Anti-TRIB2 monoclonal antibody (CABT-31503MH)

Mouse anti-Human TRIB2 monoclonal antibody for FC, ICC/IF, IHC-P, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
9E22
Species Reactivity
Human, African green monkey
Immunogen
Recombinant full length Human TRIB2 produced in HEK293T cells .
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/2000; IHC-P: 1/50.Flow Cyt: 1/100; ICC/IF:1/50.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TRIB2; tribbles homolog 2 (Drosophila); tribbles homolog 2; GS3955; TRB2; C5FW
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TRIB2 (Tribbles Pseudokinase 2) is a Protein Coding gene. Diseases associated with TRIB2 include uveitis and narcolepsy. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK40. This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Tribbles homolog 2 is a protein that in humans is encoded by the TRIB2 gene. 0The function about TRIB2 antigen include ATP binding; NOT nucleotide binding; NOT protein kinase activity; protein kinase inhibitor activity; transcription factor binding; transferase activity, transferring phosphorus-containing groups; ubiquitin protein ligase binding; ubiquitin-protein ligase.

Citations


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References


Toyoda, H; Tanaka, S; et al. Anti-Tribbles Homolog 2 Autoantibodies in Japanese Patients with Narcolepsy. SLEEP 33:875-878(2010).
Ashton-Chess, J; Giral, M; et al. Tribbles-1 as a novel biomarker of chronic antibody-mediated rejection. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 19:1116-1127(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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