Synthetic peptide, corresponding to a region within internal sequence amino acids 107-156 (AHGRAFFAAA FHRVGPPLLI EHLGLAAGGA QQDLRLCVGC GWVRGRRTGR) of Human TMEM158.
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway.
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