Anti-Substance P polyclonal antibody

Species Reactivity

Human

Immunogen

Substance P, conjugated to BSA

Conjugate

Application Notes

1:400 – 1:800 using immunofluorescence microscopy, with overnight incubation at 2-8°C.

Alternative Names

TAC1; tachykinin, precursor 1; NK2; NPK; NKNA; TAC2; Hs.2563; NKNA; TAC2,; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma); neurokinin 1; neurokinin 2; neur

Entrez Gene ID

UniProt ID

Antigen Description

Substance P occurs in nerve fibers of the central and peripheral nervous system and in endocrine cells of the gut. It stimulates smooth muscle contraction, gives rise to vasodilation and is involved in sensory functions. Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, bronchoconstriction and sudden drops in blood pressure. Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.

Pathway

Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR; Tachykinin receptors bind tachykinins; Gene Ontology.