Anti-SLC5A5 (aa 179-228) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within the internal sequence amino acids 179-228 (TAVGGMKAVV WTDVFQVVVM LSGFWVVLAR GVMLVGGPRQ VLTLAQNHSR) of Human Sodium Iodide Symporter.

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

SLC5A5; solute carrier family 5 (sodium iodide symporter), member 5; sodium/iodide cotransporter; NIS; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; Slc5a5; sodium iodide symporter; Sodium-iodide

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.

Pathway

Amine-derived hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Organic anion transporters, organism-specific biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Thyroxine biosynthesis, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem; Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specif